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There was an observed U-shape association between serum DPP-4 and mortality in patients with chronic systolic HF, and Loureno et al

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These labile copper pools are important for the assembly of iron-sulfur (FeS) clusters, which are directly linked to mitochondrial function 117,118

There is a suggestion from pooled data of increased rates of infections, specifically nasopharyngitis and urinary tract infections, which suggests a role for DPP-4 activity in normal immune surveillance, but whether this is clinically significant is still to be established

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