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[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Stupnisek M., Franjic S., Drmic D., Hrelec M., Kolenc D., Radic B., Bojic D., Vcev A., Seiwerth S., Sikiric P

The cardiometabolic benefits were consistently more pronounced in female participants, with women experiencing about a 5% reduction in total cholesterol versus 3% in men, and a 10% reduction in LDL cholesterol versus 4% in men

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T/T individuals supplementing with 5-methylfolate (active folate), methylcobalamin, and pyridoxal-5'-phosphate normalize homocysteine, restore BH4 recycling, and reduce functional methylation insufficiency across most downstream longevity mechanisms

This enzyme is specifically designed to dismantle glutathione