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Unexpectedly, SNPs related to HIF/EPO pathway genes ( EGLN1 , EGLN2 , EGLN3 , EPO , EPOR , HIF1A , PTEN , and VHL ) have failed to establish a definitive correlation with CMS susceptibility among male Peruvian Quechua natives, potentially due to flawed grouping: non-CMS controls lacked strict criteria (non-CMS: individuals with a CMS score 3000 m, prophylaxis should be strongly considered

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3a), which is well consistent with the tendency of transcriptome data from plants in response to wounding, namely, more transcripts are upregulated than downregulated 27,28

Evidence reviews caution that any recurring wellness schedule should default to the lowest effective cadence and be revisited regularly