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CJC with DAC provides continuous elevation that can desensitize receptors over time
This reaction is reversible when stored at refrigerator temperature
Whereas the oxidative PPP is considered unidirectional, the non-oxidative branch can supply glycolysis with intermediates derived from ribose 5-phosphate and vice versa , depending on the biochemical demand
instead, it provides a natural, rhythmic stimulus
This pathway involves activation of phosphatidylinositol phospholipase C (PI-PLC), phosphatidylinositol 4,5-bisphosphate (PIP 2 ) and inositol trisphosphate (IP 3 ), ultimately resulting in mobilization of intracellular Ca 2+ stores (Camia et al., 2007)
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