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Thiamine deficiency adversely affects the activity levels of these enzymes, with TK, through thiamine-dependent erythrocyte transketolase (ETK) activity, common biomarkers of thiamine status, since it is particularly sensitive to thiamine levels and AKD often exhibiting the earliest detectable changes (6, 41)

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However, alcohol increases nausea risk, and the combination with tirzepatide might be poorly tolerated, particularly during the first few weeks on a new dose

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[7, 8] However, qualitative assays cannot provide sufficient information for females

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