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Furthermore, the interplay between miRNAs and epigenetic modifications, such as DNA methylation and histone modifications, adds another layer of complexity to the regulation of inflammation in the testicular microenvironment (196)

In a recent sham-controlled, randomised clinical trial of patients with refractory gastroparesis (41% had diabetes), G-POEM achieved symptomatic improvement in 71% of participants compared with 22% following the sham procedure [80]

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