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A study showed that PYY null mice developed marked obesity that may be reversed by exogenous PYY treatment, suggesting that this hormone plays a role not only in postprandial early satiety but also in long-term, by regulating energy balance through unknown mechanism.27 Glucagon like peptide-1 (GLP-1) and oxyntomodulin (OXM) GLP-1 and OXM are products of the preproglucagon gene, which is expressed in the CNS, in the L-cells of the small intestine, and in pancreas

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Comparative studies positioning Retatrutide alongside Semaglutide and Tirzepatide have consistently reported more pronounced changes in body composition and metabolic parameters with the triple-agonist compound , establishing a clear mechanistic rationale for the triple-receptor approach in metabolic research