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Science 295 , 865868 (2002)

GLP-1 receptor agonists are licensed for type 2 diabetes and weight management, not menopausal symptoms These medications work by enhancing insulin secretion, suppressing glucagon, slowing gastric emptying, and reducing appetite Weight loss from GLP-1 therapy may theoretically influence vasomotor symptoms, but robust clinical trial evidence is lacking Hormone replacement therapy remains the most effective first-line treatment for moderate to severe hot flashes in the UK Common GLP-1 side effects include gastrointestinal symptoms, with risks of pancreatitis and gallbladder disease requiring monitoring Table of Contents What Are GLP-1 Medications and How Do They Work

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