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10.1186/1471-2202-13-33 62 IsacsonR.NielsenE.DannaeusK.BertilssonG.PatroneC.ZachrissonO.et al

Exendin-4-Fc Has an Extended t 1/2 and Produced Sustained Glucose Reduction The pharmacokinetics of Exendin-4-Fc were studied in cynomolgus monkeys after a single dose of 0.01 mg/kg or 0.1 mg/kg

It works through several complementary pathways: Appetite regulation : Acts on receptors in the hypothalamus to reduce hunger signals and increase feelings of fullness (satiety) Gastric emptying : Slows the rate at which food leaves the stomach, prolonging the sensation of fullness after meals (this effect may diminish with ongoing treatment) [6] [7] Blood glucose control : Enhances insulin secretion when blood glucose is elevated and suppresses glucagon release Clinical studies show these effects can lead to reduced caloric intake, which translates to clinically significant weight loss when maintained over time

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Practical considerations often influence route selection beyond theoretical optimization