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Morning administration in a fasted state is the most commonly cited timing because endogenous fat mobilisation is naturally elevated after an overnight fast, theoretically amplifying the lipolytic signal from the peptide

It can be perceived as withholding a medically necessary treatment, not just a preference

In cases of neuropathy caused by vitamin 12 deficiency, supplementation has been seen to improve symptoms

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Additionally, low B12 intake has also been shown to be associated with cancer [61,62]