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Reviews flag this as an unresolved question, especially in patients with current or prior cancer (Sehgal et al., Pharmaceuticals, 2025)

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Veterans Affairs healthcare facilities, patients (n = 4599) when adjusted to 25(OH)D levels from 15 to 60 ng/mL, showed a decrease in probability of COVID-19-related hospitalizations from 24.1 to 18.7%, and mortality rates from 10.4 to 5.7% 704