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Even minimal exposure can cause significant discomfort and health issues for individuals with a cobalt allergy

Only 9.5% of the patients with the DJBL procedure experienced major side effects, including severe abdominal pain in one patient and acute cholecystitis with duodenal fistula due to bulbar transmural penetration and gall bladder impaction by one of the anchors

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However, it is uncommon and challenging to statistically assess the combination of clinical, imaging, biochemical, pathological, genetic, and electrophysiological markers

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