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Before starting retatrutide (within a trial setting), your clinician should: Conduct a thorough medical history review , including assessment of conditions that may be trial exclusion criteria or require particular caution for example, a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2)

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Adequate protein intake helps maintain muscle protein synthesis even in a caloric deficit

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It may also be recommended if you have a weight issue that overlaps with a cardiovascular issue as Semaglutide GLP-1 has been found to have a positive affect on managing blood pressure