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However, it is not clear what contributed specifically to this effect on inflammation, though increasing evidence suggests that IGF-1 signaling is critical for maintaining immune cell homeostasis 44 , but the prospects of sex differences in the requirement for IGF-1 signaling in these cells is not yet known and will require further study

That's why we taper up on these medications gradually and why we can't stress the body too much in the process

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Disagreements were resolved through discussion or by consultation with a fourth author (CS)