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Comparative study of autophagy in oxaliplatin-sensitive and resistant SNU-C5 colon cancer cells

This happens when tryptophan is pushed toward the kynurenine pathway, rather than being used for serotonin production

The most common complaints are gastrointestinalnausea, cramps, or diarrheawhich usually resolve when the dose is reduced or stopped

Mechanistically, GCN5L1 inhibits ERK activation by reducing mitochondrial ROS production, leading to increased FOXO1 levels, which induce the expression of the gluconeogenic enzyme PEPCK and glucose 6-phosphatase (G6Pase)