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PD-L1 is frequently upregulated in the tumor cell microenvironment as well as in DCs, macrophages, myeloid-derived suppressor cells (MDSCs), and regulatory T cells 87,88,89,90

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It has been studied extensively for its tissue-healing, anti-inflammatory, and musculoskeletal repair properties across multiple organ systems

Mechanistically, we found that CRAT downregulation promoted OC growth and metastasis by increasing mitochondrial biogenesis to facilitate mitochondrial metabolism through reducing the acetylation of peroxisome proliferator-activated receptor- coactivator (PGC-1)