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Significant weight loss, through an effect to reduce energy intake, led to the approval of liraglutide (3.0 mg) for the treatment of obesity, an indication currently under investigation with semaglutide

Finally, co-administration of placebo tablets with oral semaglutide has been reported to reduce semaglutide exposure by 34% in a two-part, open-label, crossover trial in 45 healthy subjects [32]

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which is based primarily on data from the SURMOUNT-1 and SURMOUNT-2 studies

The critical caveat with semaglutide: weight regain after discontinuation is significant