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The bound GLP-1 (right) stabilizes a water molecule network in the proximity of the peptide N-terminal residues H7 and A8 as well of Y1521.47, T3917.46, R1902.60, E3645.53

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Mechanistically, the binding of BPC157 to FBXO22 induces steric hindrance that suppresses FBXO22-mediated ubiquitination and degradation of its substrate BACH1