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When medication switchers were excluded, the multivariable model results remained robust

As such, we did not consider open-label status as a source of bias, given that measurement of HbA 1c is an objective outcome and thus is not affected by blinding status [15]

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Whereas in vitro experiments showed that S375 is phosphorylated by GRK5 upon morphine exposure (Doll et al., 2012) and S375 phosphorylation plays a major role in MOR desensitization (Schulz et al., 2004), S375A knock-in mice still present anti-nociceptive tolerance upon acute and chronic exposure to morphine (Grecksch et al., 2011)