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Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z

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This provides a middle ground between purely systemic and directly local administration

However, LA increased hepatic cholesterol and reduced LDL receptor protein conversion regulatory factors compared with the model group despite reduced mRNA expression of hepatic cholesterol synthesis enzyme (HMG-CoAr) and blood levels of cholesterol and LDL

The mild stomach stuff in the first couple of weeks settled once I dialed in smaller, more frequent meals