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Molecules 26:4571 Pea R, Vlches J, Poblete C, Ganga MA (2020) Effect of Candida intermedia LAMAP1790 antimicrobial peptides against wine-spoilage yeasts Brettanomyces bruxellensis and Pichia guilliermondii

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Simultaneously, it upregulates the expression of the transferrin receptor (TfR), intensifying iron absorption in liver cells and resulting in hepatic iron overload

5.1 Mechanism of intranasal delivery Since William Frey II proposed intranasal administration in 1991 (Frey, 1991), this technique has emerged as a novel, non-invasive delivery system, bypassing the BBB and the systemic first-pass effect, allowing rapid onset of action