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Macro-B12 should be suspected when a markedly high value persists with no B12 exposure, sits with an unrevealing workup, and disagrees with functional markers

Its high selectivity and confirmed membrane permeability make it one of the most reliable small-molecule tools currently available for interrogating the NNMT pathway in both cell-based and in vivo experimental models

Tohkin, M

& Tavakoli, M

However, we acknowledge that other miRNAs may also be regulated by AR in DPCs/DSCs, and future research should aim to explore more miRNAs downstream of AR and establish a regulatory network of miRNAs involved in the pathogenesis of AGA