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These metabolites spanned across five key classes: Carbohydrate Metabolomics, Nucleotide and Its Metabolites, Organic Acids and Derivatives, Phosphate Sugars, and Phosphoric Acids, suggesting a metabolic realignment in response to the redox disequilibrium induced by the absence of GR

2E) but was 20-fold less potent (CS EC 50 = 2.1 M, Table S2), suggesting that further potency improvements would be required