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A vitamin B12 shortage can cause a variety of health issues, ranging from exhaustion to permanent neurological abnormalities

A good example is the finding that low circulating levels of IGF-1 are independently associated with hyperglycaemia and insulin resistance in adults [160, 230232]

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However, make sure to not exceed the dosage range of 500mcg to 600mcg per day because you might risk experiencing adverse effects

Three specific gaps separate this preclinical evidence from a human recommendation, and it is worth naming each so the framing throughout this guide is not mistaken for false modesty