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Oral pathogens, especially P.g , can upregulate hepatic flavin-containing monooxygenase 3 (FMO3) through their derived products and promote the conversion of TMA to TMAO, while simultaneously disrupting the intestinal barrier and disturbing the gut microbiota structure, forming an oralgutliver pathogenic pathway (Wang et al., 2024

The literature search was made in EBSCO, Embase, Medline/PubMed, Ovid and Web of Science electronic databases

doi:10.1038/s41574-019-0275-6 Williams JA