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On one hand, SCFAs (especially butyrate) strengthen the gut barrier and have anti-inflammatory effects that indirectly protect the BBB [75]

"The role of leptin and low testosterone in obesity." International journal of impotence research 34.7 (2022): 704-713.

Byrne, M

& Huang, Y

It may be appropriate for researchers studying metabolic effects in subjects who are sensitive to gastrointestinal side effects or who have lower baseline body weight