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The reaction mechanism for roGFP2(S 2 ) as a model non-glutathione disulfide substrate resembles the first part of the GSH-dependent reduction of the sulfenic acid of human peroxiredoxin 6 that is catalyzed by glutathione transferase P1-1 (which shares several structural features with glutaredoxins) 7,80,81,82

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For this reason, homocysteine is increasingly viewed as a marker to optimise rather than simply a value that should remain within the laboratory reference range

Glutathione in the deproteinized fraction and protein-bound fraction of plasma were determined using the method described by Park et al

10.1167/iovs.63.4.27 69 WangL.ZhangL.NiuY.SitiaR.WangC