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& Freeman, R

The primary role of NAC as an antioxidant stems from its ability to increase the intracellular concentration of glutathione (GSH), which is the most crucial biothiol responsible for cellular redox imbalance

Other examples include the recently reported ability of nuclear IGF-1R to drive chemotherapy resistance in various types of cancer, and notably, through interactions with nuclear mitotic apparatus (NuMA) protein and regulating p53binding protein 1 (53BP1) dependent DNA doublestrand break repair in colorectal cancer (40)

Granzyme K(+) CD8 T cells form a core population in inflamed human tissue

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