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However, it remains uncertain whether the doses used for diabetes management achieve sufficient central nervous system penetration to produce clinically meaningful neuroprotective effects

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Lifestyle modifications taken under consideration included the intensification of physical activity, smoking cessation, improved sleep hygiene and a diet with adequate supply of iodine and selenium [122]

Sun Y, Campisi J, Higano C, Beer TM, Porter P, Coleman I et al

None of that is a problem