Genome-wide identification of GLP-1 NotchLAG-1 CSL transcriptional targets: ChIP-seq lst-1 and sygl-1 , which were identified in a small candidate gene RNAi screen, are GLP-1 transcriptional targets that are redundantly required for the germline stem cell fate [20,21,42] ( Introduction )
And that has to do with the short chain fatty acids being good for the gut, and a lot of work done by a former colleague of mine and good friend, Mark Shigenaga, showing that the short chain citrate, malate, lactate, but specifically malate, really, and lactate are the major ones that get into the gut epithelial cells and are an energy source for the mitochondria and the goblet cells
Glutathione could be a missing piece of the puzzle
It is of interest that children with Prader-Willi syndrome, which exhibit hyperphagia and obesity have a low level of plasma PP and infusion of PP in those children leads to reduction in food intake (63)
GLP-1 Weight Loss Program Our physician-guided GLP-1 program combines evidence-based medication with ongoing lifestyle support, built around your labs and your goals