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109.1 A gender disaggregated growth curve analysis of mobility decline and its sociodemographic correlates among community-dwelling older Nigerians Ogochukwu Kelechi Onyeso 1 , Chiedozie James Alumona 1 , Akin Ojagbemi 2 , Kelechi Mirabel Onyeso 3 , Adesola C
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It inhibits NOTCH1 signaling by using its GCT activity to cleave a -glutamyl-cysteine bond at glutamate 1669 of the immature NOTCH receptor, thereby preventing the essential S1 cleavage and subsequent activation ( FIGURE 6 The physiological importance of this mechanism is underscored by severe developmental phenotypes upon its disruption
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