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Except intestinal pathologies like inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) (9, 10), varying degrees of intestinal dysbiosis also exist in other systemic diseases including obesity, diabetes, and Parkinsons disease, which may be attributed to the metabolic, immune, and neural pathways (11)

Ultimately, such insights could pave the way for precision nutrition strategies aimed at preventing or managing barrier-related disorders such as inflammatory bowel disease and support early-life or aging gut health where intestinal barrier integrity is especially vulnerable

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