Another advance was the cloning of the intercellular proteins such as zonulins, claudins, occludins, tricellulins, and the many other protein components that comprise the tight junctions, facilitating the understanding of their contributions toward junctional structure and paracellular permeability [33, 38]
The psychosocial costs such as social, educational and career related activities not pursued, as well as the emotional distress, depression, social isolation, and diminished QoL have not been measured, but are almost certainly substantial
Understanding the likely causes is a good starting point
Accurate the glucose-dependent nature is a key safety advantage
However, noticeable effects like improved sleep typically appear within 1-2 weeks, while body composition changes usually become apparent around weeks 6-8