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Furthermore, in ECL1 of GCGR there are two glycine residues (G207 ECL1 , G219 ECL1 ) that disconnect the helical structure in the active state, whereas the G219 ECL1 is not conserved in GLP-1R and the helical conformation is relatively intact in this region of GLP-1R

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Ribet D., Hamon M., Gouin E., Nahori M.A., Impens F., Neyret-Kahn H., Gevaert K., Vandekerckhove J., Dejean A., Cossart P

When the reaction time was more than 90 min, the yield of the product decreased slightly, which may be due to the polymerization of the product.Therefore, the optimal reaction time was 90 min

Torti M, Vacca L, Stocchi F

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