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For a workforce-focused analysis on GLP-1s, download Aons recent report

GLP-1 RA use was associated with a higher risk of psoriasis compared with insulin (HR 1.17, 95% CI 1.101.25), biguanides (HR 1.14, 95% CI 1.071.23), and sulfonylureas (HR 1.34, 95% CI 1.201.50), while no significant differences were observed versus SGLT2i (HR 0.99, 95% CI 0.911.07) or thiazolidinediones (HR 1.05, 95% CI 0.641.71) ( Figure 3A )

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Most safety data comes from animal studies and limited human research contexts

Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action