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10.1016/bs.acr.2017.11.003 6 BadgleyM

Clinical Screening: This necessitates rigorous cardiovascular screening and monitoring before and during treatment, particularly for patients with pre-existing cardiac rhythm issues

But they demonstrate that the muscle loss seen in clinical trials is not inevitable

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Increased intracellular Ca 2+ levels, along with reduced cAMP, elevate mitochondrial reactive oxygen species (ROS) production (Jin et al., 2022), which upregulates the Bax/Bcl-2 ratio on the mitochondrial membrane, triggering mitochondrial transmembrane potential loss and Cyt C release