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However, Pioglitazone and Saxagliptin are not recommended as Glucose-lowering agents since they are linked to an increased HF hospitalization risk [49, 98, 99]

Topalian, S

Studies tracking long-term outcomes reveal that discontinuing GLP-1 therapy without lifestyle reinforcement typically results in gradual weight regain, underscoring that these medications work best as part of a comprehensive approach including nutrition, movement, and stress management

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Colonic fermentation and proximal gastric tone in humans