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The model intracellular concentrations of Hcy, Met, and SAM all fall dramatically corresponding to the clinically observed declines in their plasma concentrations

The search terms included combinations of "TCM", "natural products", "GM", "indirect pharmacology", "liver disease", "ALD", "NAFLD", "cirrhosis", "ALI", "AIH" and "HCC." In addition, the reference lists of relevant articles were manually screened to identify additional studies, with priority given to high-quality original research and peer-reviewed reviews that provide mechanistic insights into the interactions among TCM, natural products, and liver pathology (See Fig

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