Likewise, tirzepatide effects at the GLP-1R, like other specific GLP-1RAs, may improve endothelial function, suppress the renin-angiotensin system, and exert natriuretic effects
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In this trial, 3,183 adult patients with inadequately controlled type 2 diabetes mellitus and atherosclerotic CV disease were randomized to semaglutide tablets 14 mg orally once daily or placebo for a median observation time of 16 months
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