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Importantly, recent in vivo studies have shown that genetic inhibition of FSP1 alone is sufficient to induce ferroptosis and suppress tumor growth, even in the absence of GPX4 inhibition 80,81

Histological and morphometric analysis, oil red O (ORO) staining and immunostaining Hematoxylin and eosin (H&E) staining was performed in paraffin sections of BAT, eWAT, iWAT and liver from mice

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N6-methyladenosine (m 6 A) demethylase FTO is significantly upregulated in MPP + -stimulated SK-N-SH cells, which suppresses YTH domain family protein 2 (YTHDF2) expression, promotes m 6 A demethylation of BRCA1-associated protein 1 (BAP1) and enhances BAP1 expression, upregulates p53 expression, and inhibits SLC7A11 transcription, thereby increasing MDA, Fe 2+ , and 4-HNE levels and triggering neuronal ferroptosis