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10.1038/ng.2641 7

7 Toxicity and safety data The recent studies underline its safety and easy of administration with sufficient bioavailability and tolerability both in animal and human studies

placebo, patients had mean body weight reductions of 8.4 kg vs

Arctigenin, the major active constituent of Fructus arctii , has been reported to alleviate colitis and protect against colon carcinogenesis in mice models

Unfortunately, as highlighted in recent meta-analyses, more than 50% and 75% of weight lost in conventional pharmacological and lifestyle interventions are regained in two and five years, mainly due to the bodys intrinsic desire to defend weight and preserve energy