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This pattern holds biological significance in PD in that it suggests that disease- or treatment-related effects may exert selective pressure on the microbial network in the gut without necessarily lowering the overall number of microbial species present, thereby exerting an influence on GBA signaling and L-DOPA metabolism

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doi: 10.3389/fnagi.2022.1059017 Received 30 September 2022 Accepted 12 December 2022 Published 06 January 2023 Volume 14 - 2022 Edited by Panteleimon Giannakopoulos, Universit de Genve, Switzerland Reviewed by Aarti Mishra, AbbVie, United States

A 2023 meta-analysis examined probiotic effects on metabolic outcomes across 45 randomized controlled trials