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Importantly, the GLP-1R-cholesterol binding sites identified here do not overlap with previously predicted cholesterol consensus motifs (CCM) (22) or Cholesterol Recognition Amino Acid Consensus (CRAC) motifs (52) identified for other GPCRs, confirming the theory that GPCRs lack predictable primary sequence consensus motifs for cholesterol binding (53, 54)

Salivary glutathione levels, evidence of the neutralization (scavenging) of ROS were low in patients from periodontal diseases in contrast to individuals with healthy gums.[111] Studies have demonstrated reduced amounts of salivary glutathione, GSH peroxides and thiol levels in the gingivitis and periodontitis patients as compared to the healthy group [Table 3].[72,107,111] Table 3

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