Theres also some research into DSIPs potential in neuroprotective, anticonvulsive, and antinociceptive (pain reduction) effects
10,33 With regard to the secondary outcome of HF hospitalisation, the results were neutral, with LEADER showing a non-significant relative risk reduction (RRR) of 13% with liraglutide compared with placebo and SUSTAIN-6 showing no significant difference between the semaglutide and placebo treatment groups
The glycaemic benefits are likely multifactorial, reflecting both the direct insulinotropic and glucagonostatic effects of the GLP-1 and GIP receptor components and the indirect benefits of weight reduction
En ese contexto, la carnitina se valora como apoyo por dos vas: Energtica muscular: favoreciendo el uso de grasas y mejorando la eficiencia del metabolismo mitocondrial
Tirzepatide vs semaglutide 1 mg in T2D SURPASS-2, HbA1c -2.01/-2.24/-2.30 pp, weight dose-responsive while HbA1c saturates: Frias NEJM 2021