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GLP-1R expression by immunohistochemical staining suggested that there was a marked increase in the expression in the PSCs, with activation (compare Figures 6a vs 6b)

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62 One trial that included 40 dogs compared a combination product providing 500 mg glucosamine hydrochloride and 300 mg chondroitin sulfate per 10 kg body weight, along with 70 mg of an anti-inflammatory herbal combination, 4 mg non-hydrolyzed type II collagen, and 18 mg hyaluronic acid per 10 kg of body weight, to placebo daily for 60 days

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The human pancreas cannot produce enough insulin, or the body cannot effectively use the produced insulin, which causing a pathological increase in blood sugar