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It has not been established through a controlled in-vivo human trial
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showed that DEX increased the expression levels of SLC7A11 and GPX4 and protected H9C2 cells from hypoxia/reoxygenation injury through the AMPK/GSK-3/Nrf2 axis [233]
Together, they decrease levels of TNF-, IL-6, and CRP, preventing chronic inflammation and promoting a stable biochemical environment for regeneration and repair