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Furthermore, the effects of GM-derived signals (e.g., SCFAs, LPS, or other metabolites) could be site-specific, potentially differing in their impact on trabecular versus cortical bone, or on axial versus appendicular skeleton, due to variations in local vascularity, mechanical loading, and cellular microenvironment
Dietary interventions targeting lipid metabolism represent a therapeutic avenue
Specifically, we applied transcriptomics-driven metabolic pathway analysis (TDMPA), a method that uses genome-scale metabolic models to calculate perturbations of enzymatic reactions from gene expression data 46
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Swabs of the endotracheal cannula confirmed colonisation of Pseudomonas aeruginosa
