Transcription factors such as nuclear factor erythroid related factor (Nrf2), nuclear factor kappa B (NF-kB), and AP-1 were reported to be activated by antioxidants such as curcumin, resveratrol, and quercetin (Wong et al., 2018)
Furthermore, nocturnal application of melatonin has led to an increased myelination and S100 immunoreactivity in crushed sciatic nerves compared to the daily application, whereas there was no difference between both groups in immunoreactivity against the Neurofilament200 protein (Moharrami Kasmaie et al., 2019)
Therapeutic effects tend to follow a schedule, too
Medicine (Baltimore) 2022;101:0
Author contributions AB: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Writingoriginal draft, Writingreview and editing