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Although the total number of replicates used in this study is small, the samples have high reproducibility and distinct inter-cohort and phenotype separation as manifested in distinct clustering in the PCA score plot ( Fig 2 )

The occurrence of RLS associated with oral metoclopramide therapy is infrequently documented in current literature, whereas there are several reported cases linked to its injectable form

Abbott), has been an important advancement in the treatment of autoimmune diseases such as rheumatoid arthritis

Iron contributes to normal red blood cell formation (supported by the vitamins B6 and B12) and haemoglobin formation

513 NMNAT, as a binding partner of HSP90, can specifically recognize p-Tau to inhibit its amyloid aggregation in vitro and reduce its symptoms in the fly tauopathy model, and this effect could be competitively destroyed by its enzymatic substrate