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15 These are all consistent with decongestive and disease-modifying effects of semaglutide in obesity-related HFpEF, which is further substantiated by fewer hard clinical events of HF hospitalizations and urgent visits with semaglutide vs placebo, as noted both in the STEP-HFpEF Program 6 and in the pooled analyses of the HFpEF populations from the SELECT (Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity), FLOW (A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease), STEP-HFpEF, and STEP-HFpEF DM trials

For one thing, this study clearly suffers from immortal time bias

Smyth A, Teo KK, Rangarajan S, ODonnell M, Zhang X, Rana P, et al

( c ) Measurement of Sindbis virus (SINV) replication after transfection of in vitro transcribed RNA from infectious SINV Toto-1101/Luc reporter virus with and without 0.4 mg/L riboflavin and 10 M FAD

It's also prescribed off-label for polycystic ovary syndrome (PCOS) and binge-eating disorder